Product Overview

• 2-Chloroethyl-Tetrahydro-Pyrido-Pyrimidin-4-One Hydrochloride, frequently identified across pharmaceutical validation frameworks as Risperidone Intermediate 1, is an advanced, high-purity bicyclic heterocyclic intermediate compound. Chemically, it integrates a highly reactive 2-chloroethyl halogenated side chain onto a tetrahydropyrido[1,2-a]pyrimidin-4-one bicyclic core platform, stabilized as a hydrochloride salt. ProCorBay International supplies exceptional, synthesis-ready crystalline powder blocks to global active pharmaceutical ingredient manufacturing plants and neurological drug development facilities requiring strict batch validation parameters.
• This compound is manufactured through the precise condensation of 2-aminopyridine variants or related piperidine links with chlorinated beta-ketoesters under optimized chemical pressure profiles, followed by cyclic ring-assembly, converting into its hydrochloride salt form to maximize stability, and multiple recrystallization washes to eliminate trace structural isomers. ProCorBay coordinates distribution tracks with premier heterocyclic chemical complexes to deliver material featuring ultra-low free volatile limits, minimal moisture indices, and high active chemical assays.
• Within advanced neurological drug manufacturing, this fused pyrimidinone block represents a vital regulatory key starting material. It functions as the direct structural predecessor and certified reference standard for synthesizing the blockbuster atypical antipsychotic medication Risperidone. The terminal chloroethyl chain provides an exceptional reactive node for executing direct amine coupling reactions with substituted benzisoxazole piperidine building blocks. ProCorBay acts as an integrated supply partner, providing complete analytical validation records and reliable moisture-barrier packaging to ensure trouble-free integration into synthesis streams.