2,4-Difluoroaniline

Difluoroaniline

Product Overview

    • 2,4-Difluoroaniline is an essential halogenated aromatic amine building block primarily utilized as an intermediate in synthesis routes for pharmaceuticals and specialized agrochemicals. Structurally, it features a benzene ring with two fluorine atoms fixed at positions 2 and 4 relative to the primary amino group. It is supplied as a clear, faint yellow to dark reddish-purple liquid with a characteristic aromatic amine smell. ProCorBay International distributes highly refined, synthesis-ready 2,4-Difluoroaniline to active ingredient labs requiring reliable reactivity profiles and low moisture parameters.
    • 2,4-Difluoroaniline is typically manufactured through the selective catalytic hydrogenation of 2,4-difluoronitrobenzene or direct fluorination routes, followed by fractionated vacuum distillation to achieve narrow purity margins. ProCorBay manages deep distribution lanes with premier halogenated compound producers to guarantee high chemical assays and low relative isomer impurities.
    • Within the life sciences space, this fluorinated aniline is a critical starting material for blockbusters like Diflunisal (a non-steroidal anti-inflammatory drug) and various broad-spectrum antifungal agents like Fluconazole and Voriconazole. The carbon-fluorine bond architecture introduces enhanced metabolic stability and tailored lipophilicity into final drug profiles, helping developers optimize therapeutic efficacy. ProCorBay ensures a reliable supply chain for contract research organizations (CROs) and bulk manufacturers alike.

Applications

    •  
    • Pharmaceutical Intermediates: Crucial raw material for synthesizing NSAIDs, triazole antifungals, and enzyme inhibitors.
    • Agrochemical Formulation: Used to develop specialized fluorinated crop protection fungicides and herbicides.
    • Specialty Chemicals: Key building block for custom dyes and fluorinated surface coatings.

Benefits

    • High Chemical Assay: ≥ 99.0% purity minimizes secondary reaction side-products.
    • Metabolic Enhancer: Introduces stable fluorine atoms to improve the bioavailability of final molecules.
    • Low Moisture Content: Strictly controlled hydration levels prevent unwanted side-reactions during acylation.
    • Consistent Physical Properties: Regular boiling and density profiles streamline factory vacuum distillation setups.
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Frequently Asked Questions

Aromatic amines naturally form trace oxidation complexes upon subtle exposure to light or ambient oxygen, turning the clear liquid slightly dark. This typically does not impact primary synthesis performance if the overall assay remains within spec.

The localized fluorine atoms alter the electron density of the aromatic ring, dramatically modifying the drug molecule's biological stability and receptor binding.