4-Hydroxy-2H-Chromen-2-One (4-Hydroxycoumarin)

4-Hydroxy-2H-Chromen-2-One (4-Hydroxycoumarin)

Product Overview

    • 4-Hydroxy-2H-Chromen-2-One, widely designated across industrial and pharmaceutical networks as 4-Hydroxycoumarin, is a premier organic intermediate compound. It acts as a critical molecular scaffold for developing advanced anticoagulant medications and high-efficiency rodenticide actives. Commercially supplied as a fine, off-white to light yellow crystalline solid powder, it delivers excellent solubility parameters across common organic solvent bases. ProCorBay International distributes exceptional, high-purity 4-Hydroxycoumarin to global pharmaceutical synthesis plants, agrochemical blending operations, and custom chemical research teams.
    • 4-Hydroxycoumarin is manufactured through the intramolecular condensation of o-acetylsalicoyl chloride or via the reaction of methyl salicylate with sodium metal, followed by acid precipitation and multi-step recrystallization. ProCorBay coordinates active distribution chains with advanced specialty chemical synthesis operations to supply product streams featuring low total moisture parameters and high active chemical assays. 
    • Within the life sciences and agricultural domains, this benzopyran derivative is highly valued for its unique biological interaction mechanism. It serves as the primary starting block for synthesizing blockbuster vitamin K antagonists, including Warfarin, Phenprocoumon, and Acenocoumarol. The hydroxy modification on the coumarin ring system allows for easy chemical substitution, helping formulators attach functional organic groups smoothly. ProCorBay maintains robust, year-round inventory lanes to ensure seamless supply continuity for your chemical processing configurations.

Applications

    • Pharmaceutical Intermediates: Crucial starting raw material for synthesizing oral anticoagulants and cardiovascular therapeutic blocks.
    • Agrochemical Formulation: Essential active precursor utilized to manufacture high-potency coumarin-type anticoagulant rodenticides.
    • Specialty Chemicals: Key structural building block used in formulating fluorescent dyes and custom laboratory testing markers.

Benefits

    • High Chemical Assay: \(\ge \) 98.0% minimum purity profile limits unwanted isomer variations during organic coupling.
    • Versatile Coumarin Core: Hydroxy attachment site allows smooth functional group substitution under standard processing temperatures.
    • Low Moisture Content: Strictly controlled hydration margins prevent early decomposition during chlorination or acylation loops.
    • Excellent Organic Solubility: Dissolves quickly in alcohols and organic solvents, accelerating batch cycle throughputs.
    • Documented Safety Records: Backed by decades of consistent formulation data across pharmaceutical and agrochemical industries.
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Frequently Asked Questions

While it serves as a precursor to potent anticoagulants, the pure intermediate powder exhibits moderate toxicity. Follow material safety datasheets (MSDS) and avoid direct dust inhalation.

Yes, it demonstrates characteristic fluorescence emission properties around 373 nm when dissolved in pure methanol vehicles.