Tert-Butylamino-1,2-Propanediol

Tert-Butylamino-1,2-Propanediol

Product Overview

    • Tert-Butylamino-1,2-Propanediol is an essential chiral and racemic building block. It is widely leveraged across the specialty pharmaceutical synthesis industry. Chemically, it combines a bulky tert-butyl secondary amine with a propanediol carbon string. This structural geometry provides excellent targeted reactivity for amine-coupling procedures. ProCorBay International distributes exceptional, synthesis-ready grades to active ingredient facilities. We guarantee high batch validation parameters and very narrow isomer distribution ranges. 
    • This compound is manufactured via the precise ring-opening reaction of epichlorohydrin or glycidol. The reaction uses high-purity tert-butylamine under optimized temperature and chemical pressure. Multiple fractionated vacuum distillation passes follow to remove volatile secondary fragments. ProCorBay sources this chemical block from advanced halogenated and amine conversion facilities. These locations maintain full cosmetic and pharmaceutical regulatory ingredient standard alignments. 
    • In modern healthcare manufacturing, it serves as a critical structural predecessor. It is key for synthesizing cardiovascular agents like Timolol Maleate. The tert-butylamino segment provides necessary steric hindrance for receptor binding profiles. It helps developers create stable anti-glaucoma and beta-blocking drug formulations. ProCorBay manages deep, consistent distribution pipelines to prevent seasonal factory shortfalls. We guarantee continuous delivery to international compounding manufacturing plants.

Applications

    • Pharmaceutical Intermediates: Primary building block utilized to synthesize Timolol and related beta-blockers.
    • Chiral Synthesis: Specialized amino-diol intermediate leveraged for custom chiral catalyst configurations.

Benefits

    • Steric Hindrance Advantage: Tert-butyl amine branch delivers precise targeted receptor configuration.
    • High Chemical Assay: \(\ge \) 98.0% minimum purity profile limits unwanted side products.
    • Low Volatile Residues: Deep distillation cycles eliminate free tert-butylamine traces completely.
    • Excellent Formulation Blending: Low melting point mass blends smoothly within fluid vehicles.
    • Documented Quality Logs: Full lot tracking records guarantee predictable performance in blenders.
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Frequently Asked Questions

Its melting point sits close to standard ambient room temperature (~42-45°C or variable based on chirality). Warm weather causes gentle liquefaction. It remains fully within specification.

Yes. Every chiral batch includes specific polarimeter measurements on the Certificate of Analysis.